Under a plan to set up a global production network, Astra enlisted contract manufacturer Lonza a year ago to produce the antibody treatment in Portsmouth, New Hampshire, starting in the first half of 2021. The government declined to provide an update. provided $23.7 million in early funding for the development project.īritain's government also has an in-principle agreement over a million doses of AZD7442. contract a year ago for initial supplies of 200,000 doses. The company agreed in March to supply up to half a million extra doses of the antibody cocktail to the United States. Talks regarding supply agreements for AZD7442 are ongoing with the United States and other governments, AstraZeneca said. authorisation for AZD7442 - based on antibodies discovered by Vanderbilt University Medical Center in the United States - could be a major win for AstraZeneca, whose widely used COVID-19 vaccine has yet to be approved by U.S.
#CLASS 1 DRUGS TRIAL#
The positive trial data was published in August.Ī U.S. In a statement on Tuesday, the Anglo-Swedish drugmaker said it included data in its filing with the FDA from a late-stage trial that showed the drug reduced the risk of people developing any COVID-19 symptoms by 77%. Another trial is ongoing to test the drug as a treatment of the infected. AstraZeneca's application is however for prevention before any exposure.Īstra's AZD7442 fell through in the post-exposure setting in a trial in June. Food and Drug Administration authorized Regeneron's drug in September for use in preventing COVID-19 after exposure to infected people. The drug, given in two sequential injections, could also supplement a vaccination course for those, such as military personnel, who need to booster their protection further, AstraZeneca has said. The AstraZeneca therapy, designed to last several months to a year, could protect people who do not have a strong enough immune response to COVID-19 vaccines due to, for instance, chemotherapy or anti-rejection drugs after organ transplants. While vaccines rely on an intact immune system to develop targeted antibodies and infection-fighting cells, Astra's biotech compound known as AZD7442 contains lab-made antibodies designed to linger in the body for months to contain the virus in case of an infection.ĬOVID-19 therapies based on the same class of monoclonal antibodies are sold by rivals Regeneron, Eli Lilly and GlaxoSmithKline and its partner Vir to stop the disease from worsening during early, milder stages of the infection. regulators for its antibody cocktail, the first protective shot other than vaccines against COVID-19, another potential major step in the global fight to combat the virus. Oct 5 (Reuters) - AstraZeneca has requested emergency approval from U.S.
* Part of monoclonal antibody drug class (Writes through) * Addressing people with weakened immune system * Could offer an alternative advance protection for COVID-19
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